The Wagenblast Lab opened in June 2022! The central question of our lab is to understand how a normal blood stem cell can become cancerous. In leukemia, the initiating genetic mutations occur as early as during fetal development. Our team applies cutting-edge CRISPR/Cas9 genome editing approaches in human primary blood stem cells to model the pre-leukemic and leukemic phases of acute myeloid and acute lymphoblastic leukemia in vivo. The goal is to uncover insights into the genetic, cellular and developmental mechanisms of leukemia, with a particular focus on childhood leukemia, and identify therapeutic vulnerabilities of the disease.

Our lab strives to be a diverse, creative and dynamic place. We are committed to establish an inclusive and equitable environment in our lab to allow every lab member to achieve their goals and advance their career. We love to collaborate with other scientists and connect our science to people!

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We are looking for talented and motivated PhD Students, Postdoctoral Fellows and Laboratory Technicians to join our lab. We encourage applications from underrepresented or minority groups. Interested applicants should send their CV with a cover letter to us.

Prospective PhD Students should apply directly to the Mount Sinai PhD Program in Biomedical Sciences and choose the Cancer Biology or Development, Regeneration, and Stem Cells track.