FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells
Blood, Jan 26, 2025
Araújo JL, Wagenblast E, Voisin V, McLeod J, Gan OI, Bansal S, Jin L, Mitchell A, Gratton B, Cutting SK, Arruda A, Doedens M, Travas A, Kim DDH, Capo-Chichi JM, Abelson S PhD, Minden MD, Wang JC, Sobrinho-Simões MA, Pinto-do-Ó P, Lechman ER, Dick JE
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Nature Immunology, Jan 26, 2025
Belabed M, Park MD, Blouin CM, Balan S, Moon CY, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid AM, Yatim N, Boumelha J, Azimi CS, LaMarche NM, Troncoso L, Amabile A, Le Berichel J, Chen ST, Wilk CM, Brown BD, Radford KJ, Ghosh S, Rothlin CV, Yvan-Charvet L, Marron TU, Puleston DJ, Wagenblast E, Bhardwaj N, Lamaze C, Merad M
An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup
Science Translational Medicine, Jan 26, 2025
Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax
Nature, Dec 12, 2024
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP
Models to study myelodysplastic syndrome and acute myeloid leukaemia
Current Opinion in Hematology, Nov 28, 2024
Chao C, Martinez IG, Wagenblast E
Down syndrome and leukemia: from basic mechanisms to clinical advances
Haematologica, Oct 02, 2023
Baruchel A, Bourquin JP, Crispino J, Cuartero S, Hasle H, Hitzler J, Klusmann JH, Izraeli S, Lane AA, Malinge S, Rabin KR, Roberts I, Ryeom S, Tasian SK, Wagenblast E
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome
Leukemia, Sep 21, 2022
Boutzen H, Madani Tonekaboni SA, Chan-Seng-Yue M, Murison A, Takayama N, Mbong N, Wagenblast E, Orouji E, Arruda A, Mitchell A, Notta F, Minden MD, Lupien M, Kaufmann KB, Dick JE