Highlighted Publications

Models to study myelodysplastic syndrome and acute myeloid leukaemia

Current Opinion in Hematology, Nov 28, 2024

We recently wrote a review on the diverse models used to study myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), highlighting their applications and limitations in understanding disease biology and testing therapies. The article focuses on genetically engineered mouse models, human iPSC-derived systems, patient-derived xenografts, and engineered blood stem cells, emphasizing their contributions to advancing translational hematology research.

Mapping the cellular origin and early evolution of leukemia in Down syndrome

Science, Jul 09, 2021

We utilized CRISPR/Cas9-mediated genome editing in human primary disomic and trisomic hematopoietic stem cells to generate an in vivo model of Down syndrome associated leukemia evolution. This humanized model enabled us to study the mechanism of predisposition, preleukemia initiation and leukemic transformation in order to identify potential therapeutic targets of the disease.

Publications Archive

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells

Blood, Jan 26, 2025

Araújo JL, Wagenblast E, Voisin V, McLeod J, Gan OI, Bansal S, Jin L, Mitchell A, Gratton B, Cutting SK, Arruda A, Doedens M, Travas A, Kim DDH, Capo-Chichi JM, Abelson S PhD, Minden MD, Wang JC, Sobrinho-Simões MA, Pinto-do-Ó P, Lechman ER, Dick JE

Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer

Nature Immunology, Jan 26, 2025

Belabed M, Park MD, Blouin CM, Balan S, Moon CY, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid AM, Yatim N, Boumelha J, Azimi CS, LaMarche NM, Troncoso L, Amabile A, Le Berichel J, Chen ST, Wilk CM, Brown BD, Radford KJ, Ghosh S, Rothlin CV, Yvan-Charvet L, Marron TU, Puleston DJ, Wagenblast E, Bhardwaj N, Lamaze C, Merad M

An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup

Science Translational Medicine, Jan 26, 2025

Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN

The crossroads of clonal evolution, differentiation hierarchy and ontogeny in leukemia development

Blood Cancer Discovery, Dec 12, 2024

Sturgeon CM, Wagenblast E, Izzo F, Papapetrou EP

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax

Nature, Dec 12, 2024

Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP

LIPA-frogging blast phase chronic myeloid leukemia: hopping over resistance with lysosomal targeting

Haematologica, Dec 12, 2024

Quijada-Álamo M, Freed G, Wagenblast E

Models to study myelodysplastic syndrome and acute myeloid leukaemia

Current Opinion in Hematology, Nov 28, 2024

Chao C, Martinez IG, Wagenblast E

Epitope base editing: Non-malignant stem cells are going undercover

Cell Stem Cell, Nov 13, 2023

Saniei S, Wagenblast E

Down syndrome and leukemia: from basic mechanisms to clinical advances

Haematologica, Oct 02, 2023

Baruchel A, Bourquin JP, Crispino J, Cuartero S, Hasle H, Hitzler J, Klusmann JH, Izraeli S, Lane AA, Malinge S, Rabin KR, Roberts I, Ryeom S, Tasian SK, Wagenblast E

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome

Leukemia, Sep 21, 2022

Boutzen H, Madani Tonekaboni SA, Chan-Seng-Yue M, Murison A, Takayama N, Mbong N, Wagenblast E, Orouji E, Arruda A, Mitchell A, Notta F, Minden MD, Lupien M, Kaufmann KB, Dick JE